Bioinks Celluid GM
GelMA (gelatin methacryloyl) is a hydrophilic material composed of a natural polymer, gelatin, and acrylate. It has high water content and similar characteristics to the extracellular matrix (ECM), making it suitable for various applications such as drug delivery, biomaterials, and artificial organ chips due to its biocompatibility and biodegradability. GelMA also contains an arginine-glycine-aspartic acid (RGD) protein structure that promotes cell attachment. Its high solubility and low antigenicity make it a widely used material for bioinks.
Clecell produces GelMA, which can be adjusted to low concentration for cell mobility or high concentration for structural formation. By including a photoinitiator, Clecell has created a bioink that can form three-dimensional structures under UV exposure. Celluid GM, Clecell’s product, is a freeze-dried sponge product that can be adjusted to the user's desired concentration and includes a separate photoinitiator package. Currently, Clecell is researching various micro artificial tissues, including bone, cartilage, skin, and blood vessels, using Celluid GM.
Bioprinting ProtocolCollagen VS Celluid™ GM Cell viability
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Collagen
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Celluid™ GM
Clecell’s Celluid Special Features
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01
Bioink in freeze-dried solid form
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Easy to use and store as a sponge-type bioink rather than a solution type bioink
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Long-term storage available (up to 6 months when frozen)
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02
Bioinks optimized for our 3D bioprinters (UV + enzymatic crosslinking available)
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When performing UV crosslinking of GELMA, if you induce crosslinking by spraying enzyme (transglutaminase) using the nebulizer of our 3D bioprinter, you can quickly induce cross-linking even if you add a small amount of photoinitiator (crosslinker, irgacure2595) (a substance that causes cytotoxicity), and you can realize output with morphologically stable and low cytotoxicity.
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When high elasticity outputs such as hard tissues (ligaments, cartilage, bone) are required, enzymatic (transglutaminase) crosslinking can be induced in GELMA with the same amount of photoinitiator as UV cross-linking alone.
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Fast cross-linking (less than 180 sec)
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03
Customized Bioink
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User can adjust the viscosity of the bioink to suit their application, and mix and match with other bioinks or culture supplement
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Can be used by researchers using other 3D bioprinters or not using 3D bioprinters
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Can be made from soft to hard tissue
Viscosity >100 cPs: soft tissue
(vessel, skin, nerve)
Viscosity 300~500 cPs: hard tissue
(convex, ligament, bone)
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Specifications
| Product Number | CBG-101 |
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| Synonymous | GelMA, GelMA lyophilizate, Methacrylated gelatin, Gelatin methacrylate, and gelatin methacryloyl |
| pH | 7.4 |
| Degree of methacrylation | > 90% |
| Cell viability | > 90% viable fibroblast for 1 week |
| Shelf life | Minimum of 6 months from date of receipt |
| Storage condition | -20 ℃ / 4 ℃, Light and moisture sensitive |
| Form | Lyophilized sponge |
| Gelatin source | Type B, 300 Bloom, Bovine |
| Intended use | Biocompatible material for 3D bioprinting, Research grade. For research use ONLY. |
